Mixed lineage kinase domain-like (MLKL) Protein - Making Innovative Chronic Inflammatory Diseases Treatments Possible.
Chronic inflammatory disease is a medical condition which is characterized by Prolonged inflammation. Patient suffers from chronic inflammation has a progressive shift in the type of cells at the sites of inflammation. Meanwhile, a simultaneous destruction and healing of tissue occur in the process.The development of a chronic inflammation is because of the inappropriate response developed by the immune system to something it has come across with. Causative agents includes pathogens, viruses and other foreign persistent bodies. In some cases, the diseases are due to the development of autoimmune reactions.
On September 5th 2013, ScienceDaily®, the popular internet's science news media, has published an article telling that a group of Australian scientists have revealed the structure of a Mixed lineage kinase domain-like (MLKL) protein, which is essential for triggering the unusual programmed cell death, necroptosis. This finding makes possible the development of new drugs to treat chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis.
In this website, our team will evaluate this medical breakthrough by investigating the biochemistry behind the MLKL protein. To a certain extent, the website would also cover the biochemical interaction between the protein and the signalling pathway, necroptosis.